| 摘要 |
The invention provides isolated nucleic acids molecules, designated TLCC-4 and TLCC-5 nucleic acid molecules, which encode novel TRP-like calcium channel molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TLCC-4 or TLCC-5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TLCC-4 or TLCC-5 gene has been introduced or disrupted. The invention still further provides isolated TLCC-4 or TLCC-5 polypeptides, fusion polypeptides, antigenic peptides and anti-TLCC-4 or anti-TLCC-5 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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