PROCESS FOR THE PREPARATION OF 5-PHENYLPENTANOYL-ALA-ARGL-{2-[3-AMINO-2-OXOPYRROLIDIN-1-YL]PROPIONYL}-ALA-ARG-ALA-4-AMINOPHENYLACETAMIDE

摘要

A process for the preparation of a salt of 5-phenylpentanoyl-(S)-arginyl-(S)-alanyl-{(S)-2-[(R)-3-amino-2-oxopyrrolidin-1-yl]propionyl}-(S)-alanyl-(S)-arginyl-(S)-alanyl-4-aminophenylacetamide (SEQ ID NO: 1) which comprises deprotection of a compound of the formula II or a salt thereof: wherein Pg and R<1> are defined in the description. Also claimed are intermediates used in the process and the processes for the preparation of the intermediates.