发明名称 |
METHODS OF MHC CLASS II EPITOPE MAPPING, DETECTION OF AUTOIMMUNE T CELLS AND ANTIGENS, AND AUTOIMMUNE TREATMENT |
摘要 |
The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
|
申请公布号 |
WO02080963(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
WO2002US12753 |
申请日期 |
2002.04.05 |
申请人 |
VIRGINIA MASON RESEARCH CENTER |
发明人 |
KWOK, WILLIAM;NEPOM, GERALD;GEBE, JOHN;REIJONEN, HELENA;LIU, ANDREW |
分类号 |
A61K39/00;G01N33/50;G01N33/564;G01N33/569;(IPC1-7):A61K39/00;A61K39/385;C12P21/06;C12N15/09;C07K1/00 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|