ANTI-OSTEOPONTIN ANTIBODY AND USE THEREOF

摘要

An anti-osteopontin antibody inhibiting the biding of an integrin to osteopontin or its fragment which inhibits the binding of the integrin recognizing RGD sequence to osteopontin or its fragment and recognizes SVVYGLR sequence or a sequence equivalent thereto. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.