PREPARATION OF FORMULATIONS OF ANGIOTENSIN II AT1 RECEPTORS ANTAGONISTS FOR THE TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULARILLNESSES AND ITS COMPLICATIONS

摘要

Preparation of AT1 receptors antagonists formulations using the cyclodextrin s, their derivatives and/or biodegradable polymers for the treatment of arteria l hypertension, other cardiovascular disease and their complications. Until no w, no applications using the AT11 receptor antagonists and cyclodextrins or derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular diseases and their complications, was fou nd in the technical state of art. The present invention is characterized by the combination of two different technologies: one is the molecular encapsulatio n of AT11 receptor antagonists in cyclodextrins and the other is the microencapsulation in biodegradable polymers. It also comprises the increase of the effectiveness of the AT11 receptor antagonists as well as an increase in their bio-availability. The present invention comprises a new more effective alternative for the treatment of arterial hypertension, other cardiovascular diseases and their complications.