发明名称 |
Screening method for modulation of human mast cell activation |
摘要 |
Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesireable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatments of those disorders. Methods of treatment using agents, and in vitro screening assays for selection of the therapeutic agents, are described.
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申请公布号 |
US6465441(B2) |
申请公布日期 |
2002.10.15 |
申请号 |
US20010027052 |
申请日期 |
2001.12.20 |
申请人 |
DUSKA SCIENTIFIC CO. |
发明人 |
PELLEG AMIR;SCHULMAN EDWARD S. |
分类号 |
A61K45/00;A61K31/185;A61K31/52;A61K31/53;A61K31/655;A61K31/70;A61K31/7076;A61K31/715;A61P11/06;A61P37/08;A61P43/00;C12Q1/00;G01N33/53;G01N33/567;(IPC1-7):A61K31/70 |
主分类号 |
A61K45/00 |
代理机构 |
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地址 |
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