发明名称 |
CONTROL OF GROWTH AND REPAIR OF GASTRO-INTESTINAL TISSUES BY GASTROKINES AND INHIBITORS |
摘要 |
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the protein candidates for therapies in inflammatory bowel disease and gastric ulcers. |
申请公布号 |
WO02078640(A2) |
申请公布日期 |
2002.10.10 |
申请号 |
WO2002US09885 |
申请日期 |
2002.03.29 |
申请人 |
UNIVERSITY OF CHICAGO;TOBACK, GARY, F.;MARTIN, TERRENCE, E.;WALSH-REITZ, MARGARET |
发明人 |
TOBACK, GARY, F.;MARTIN, TERRENCE, E.;WALSH-REITZ, MARGARET |
分类号 |
A01K67/027;A61K38/00;A61P1/00;A61P1/04;A61P29/00;A61P43/00;C07K14/475;C07K14/52;C07K16/22;C07K16/24;C12N5/06;C12N5/08;C12N15/09;C12N15/19;C12P21/02 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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