发明名称 |
Method for chromosomal rearrangement by consecutive gene targeting of two recombination substrates to the deletion endpoints |
摘要 |
The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated.
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申请公布号 |
US6461818(B1) |
申请公布日期 |
2002.10.08 |
申请号 |
US20000552626 |
申请日期 |
2000.04.19 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
BRADLEY ALLAN;RAMIREZ-SOLIS RAMIRO;LIU PENTAO;SU HONG;ZHENG BINHAI |
分类号 |
A01K67/027;C12N15/10;C12N15/85;C12N15/90;(IPC1-7):C12Q1/68;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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