摘要 |
Compounds of general formula (1) are described: wherein =W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XRa group where X is -O-, -S(O)m-[where m is zero or an integer of value 1 or 2], or -N(Rb)-[where Rb is a hydrogen atom or an optionally substituted alkyl group] and Ra is a hydrogen atom or an optionally substituted alkyl group or, (2) =N-; L is (1) a -C(R)=C(R1)(R2) or [-CH(R)]nCH(R1)(R2) group; is (2) a -(Xa)nAlk'Ar', or Alk'XaAr' group; or is (3) XaR1; Z is a group (A), (B), (C) or (D): wherein Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; Z1 is a group -NR12C(O)-[where R12 is a hydrogen atom or an optionally substituted alkyl or (Alk)tAr group], -C(O)NR12-, -NR12C(S)-, -C(S)NR12-, -C=C-, -NR12SO2-, or -SO2NR12-; Alk is an optionally substituted straight or branched alkyl chain optionally interrupted by an atom or group X; t is zero or an integer of value 1, 2 or 3; R3 is a hydrogen or a fluorine atom or an optionally substituted straight or branched alkyl group or an OR11 group [where R11 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, alkanoyl, formyl, carboxamido or thiocarboxamido group]; R4 is a hydrogen atom or an optionally substituted alkyl, -CO2R8, -CSNR9R10, -CN, -CH2CN, or -(CH2)tAr group where t is zero or an integer of value 1, 2 or 3 and Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; provided that when L is a group of type (2) or (3) above then Z is a group of type (A) or type (B) in which R4 is a -(CH2)tAr group; R5 is a group -(CH2)t</subscript
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