发明名称 |
TRANSGENIC ANIMALS EXPRESSING ANTIBODIES SPECIFIC FOR GENES OF INTEREST AND USES THEREOF |
摘要 |
The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the product of a gene of interest that has been functionally disrupted in the transgenic animal. Furthermore, the methods and compositions of the invention are suitable for use in the treatment, diagnosis, and imaging of disease.
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申请公布号 |
WO02076196(A1) |
申请公布日期 |
2002.10.03 |
申请号 |
WO2002US08911 |
申请日期 |
2002.03.22 |
申请人 |
ABBOTT GMBH & CO. KG;GHAYUR, TARIQ |
发明人 |
GHAYUR, TARIQ |
分类号 |
A01K67/027;A61K39/395;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P7/02;A61P7/04;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P17/00;A61P17/06;A61P19/02;A61P25/14;A61P25/16;A61P25/28;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P37/02;A61P37/08;C07K16/24;C12N5/10;C12N15/09;C12N15/85;C12P21/08;(IPC1-7):A01K67/027;A01K67/033;C12P21/00;C07K16/00;C12N5/00;C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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