发明名称 FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS.
摘要 <p>The invention comprises novel compounds of formula E-B-(Alk)p-Q-(Alk)q-A-G wherein G is a radical of formula (I), (II) or (III) that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as agr;vbgr;3, agr;vbgr;5, agr;vbgr;6 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.</p>
申请公布号 MXPA02003120(A) 申请公布日期 2002.09.30
申请号 MX2002PA03120 申请日期 2000.09.27
申请人 AMGEN INC. 发明人 CELIA DOMINGUEZ
分类号 A61K31/55;A61P7/00;A61P9/00;A61P9/10;A61P17/02;A61P19/08;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P35/04;A61P43/00;C07D213/74;C07D223/16;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D405/06;C07D405/14;C07D417/12;C07D471/04;C07D471/14;C07D487/04;C07D519/00 主分类号 A61K31/55
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