Vaccines comprising a nucleic acid vector encoding the G protein of respiratory syncytial virus (RSV)

摘要

An immunogenic composition comprises a vector that cannot replicate in the respiratory tract of the host and a pharmaceutically acceptable carrier. The vector comprises a first nucleotide sequence encoding a RSV G protein, in which the transmembrane coding sequence and upstream sequence are absent, a promoter sequence operatively coupled to the first nucleotide sequence and a second nucleotide sequence located between the first nucleotide sequence and the promoter sequence. The composition generates protective antibodies to respiratory syncytial virus (RSV) G protein in the host. A vector, comprising a first nucleotide sequence encoding a RSV G protein and a promoter sequence operatively linked to the first nucleotide sequence, is used in the manufacture of a medicament that is suitable for immunizing against infection caused by RSV. The vector may further comprise a heterologous signal peptide encoding nucleotide sequence, wherein the signal peptide preferably encodes human tissue plasminogen activator. The promoter is preferably an immediate early cytomegalovirus promoter.