| 摘要 |
An oral compacted composition comprising a pharmaceutically effective amount of entacapone, nitecapone or a pharmaceutically acceptable salt thereof and a cross-linked cellulose derivative. Also described is a method for preparing an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof, wherein the method comprises: i) Mixing a pharmaceutically effective amount of entacapone, nitecapone, or a pharmaceutically acceptable salt thereof, one or more auxiliary agents and a cross-linked cellulose derivative to obtain a first mixture; ii) Compacting and crushing the first mixture one or more times to obtain a plurality of granules; iii) Adding a lubricant, a glidant, or a mixture thereof to the granules to obtain a second mixture; and iv) Compressing the second mixture into a plurality of tablets.
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