发明名称 |
A DNA MOLECULE ENCODING A VARIANT PARAOXONASE AND USES THEREOF |
摘要 |
This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as to a method and a kit for detecting a risk of cancer, coronary or cerebrovascular disease, hypertension, type 2 diabetes, dementia, joint arthrosis, cataract, or sensitivity to organophosphorus compounds in a subject, the method comprising isolating genomic DNA from said subject, determining the allelic pattern for the codon 102 of the paraoxonase encoding <i>PON1</i> gene in the genomic DNA, identification of Ile101Val mutation indicating said risk being increased and for targeting paraoxonase activity modulating therapies. Further this invention relates to transgenic animals comprising a human DNA molecule encoding said variant paraoxonase and to a method of phenotype-targeted gene sequencing. |
申请公布号 |
WO02074230(A2) |
申请公布日期 |
2002.09.26 |
申请号 |
WO2002FI00231 |
申请日期 |
2002.03.20 |
申请人 |
OY JURILAB LTD;SALONEN, JUKKA, T.;MARCHESANI, MARJA;TUOMAINEN, TOMI-PEKKA;KAIKKONEN, JARI |
发明人 |
SALONEN, JUKKA, T.;MARCHESANI, MARJA;TUOMAINEN, TOMI-PEKKA;KAIKKONEN, JARI |
分类号 |
A61P19/02;A61P25/28;A61P27/12;A61P35/00;C12N9/18;C12N15/12;C12Q1/68 |
主分类号 |
A61P19/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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