| 摘要 |
This invention provides a compound of the following formula: (see fig. I) or the pharmaceutically acceptable salts thereof, preferably wherein Ar is heteroaryl; X1 and X2 are independently selected from halo, C1-C4 alky l, hydroxy, C1-C4 alkoxy, amino, C1-C4 alkanoyl, carboxy, carbamoyl, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, or the like; R1 is selected from hydrogen, straight or branch ed C1-C4 alkyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, phenyl , heteroaryl and the lik e; R2 and R3 are independently selected from hydrogen, halo, C1-C4 alkyl, phenyl and t he like; or R1 and R2 can form, together with the carbon atom to which they are attached, a C5-C7 cycloalkyl ring; and m and n are independently 0, 1, 2 or 3. These compounds and pharmaceutical compositions containing such compounds a re useful as analgesics and anti-inflammatory agents.
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