发明名称 Anti-HIV infection agents and method for treating HIV infection
摘要 The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the formulae (I) and (II):wherein R1, R2 and R3 are the same or different and each represents alkyl group having 1 to 4 carbon atoms, R4, R5 and R6 are the same or different and each represents alkyl group having 5 to 10 carbon atoms, and X- represents a physiologically acceptable monovalent anion. The present invention also relates to a method for treating or preventing HIV infection diseases, which includes administering the photosensitizing dye. A daily dose of the photosensitizing dye is usually 2 to 100 mug, and preferably 5 to 40 mug, per kg body weight. Administration of the photosensitizing dye to HIV infected subjects leads to improvement or cure of the symptoms of AIDS related complex and increase in CD4-positive lymphocytes, which is effective for the treatment of HIV infection diseases.
申请公布号 US6455555(B1) 申请公布日期 2002.09.24
申请号 US20010868742 申请日期 2001.06.20
申请人 KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO 发明人 NAKAGAWA YOSHINORI;NIIYAMA TAKEHIRO;TSUBOI SATOSHI
分类号 A61K31/427;A61K31/4709;A61K41/00;C07D215/12;C07D277/22;(IPC1-7):A61K31/441;A61K31/47;C07D453/02;C07D277/04 主分类号 A61K31/427
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