| 摘要 |
Oligoguanylic acid inhibits the activity of Ribosome Recycling Factor (RRF), a soluble factor responsible for disassembly of the post-termination complex. RRF is essential for all bacteria because it is required for the recycling of spent ribosomes to initiate the translation of another mRNA into another polypeptide. As eukaryotic cytoplasmic protein synthesis does not require RRF, inhibitors of RRF will be efficacious as an anti-bacterial agent. The present invention provides oligoguanylic acid, sd-G4, or derivatives thereof, in particular, to serve as a lead compound for the development of novel anti-bacterial therapeutic agents.
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