发明名称 |
ASSAY |
摘要 |
A method for the identification of a modular of the interaction between latency associated peptide (LAP) of transforming growth factor beta 3 (TGF- beta 3) and alpha v integrin, which method comprises: (a) providing, as a first component, LAP- beta 3 or a functional variant thereof; (b) providing, as a second component, and alpha v integrin or a functional variant thereof; (c) contacting the two components with a test product under conditions that, in the absence of the test product, would permit the two components to interact; and (d) determining whether the test product is capable of modulating the interaction between the first and second components, thereby to determine whether the test product is a modulator of the interaction between LAP- beta 3 and the integrin. |
申请公布号 |
WO02073213(A2) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2002GB01212 |
申请日期 |
2002.03.14 |
申请人 |
GLAXO GROUP LIMITED;BARRY, SIMON;HORGAN, CARMEL;LUDBROOK, STEVEN;MILLER, DAVID |
发明人 |
BARRY, SIMON;HORGAN, CARMEL;LUDBROOK, STEVEN;MILLER, DAVID |
分类号 |
C12Q1/02;A61K38/00;A61K39/395;A61K45/00;A61P9/10;A61P13/10;A61P19/04;A61P19/10;A61P29/00;A61P35/00;C07K14/52;G01N33/68 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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