| 摘要 |
<p>A process for the preserving collagen-based tissues involves procuring the collagen-based tissue; treating the tissue in a detergent solution; treating the tissue in an enzyme solution; treating the tissue so as to prevent or inhibit the molecular crosslinking of processed tissues via the Maillard reaction and the subsequent formation of advanced glycosylation end products; treating the tissue so as to prevent or inhibit the molecular crosslinking of processed tissues via reactive oxidative species of molecules; treating the tissue so as to prevent or inhibit the molecular crosslinking of processed tissues via the formation and propagation of molecular free radicals; treating the tissue in a cryopreservation solution; and cryopreserving the tissue. The process may be utlized to preserve several differing types of collagen based tissue including heart valve, vascular grafts including veins and arteries, umbilical vessels, nerve and nervous system tissue, dura, dermis and other similar collagen based tissues.</p> |
