发明名称 |
Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5 |
摘要 |
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.
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申请公布号 |
US6451982(B1) |
申请公布日期 |
2002.09.17 |
申请号 |
US20000537911 |
申请日期 |
2000.03.28 |
申请人 |
SCHERING CORPORATION |
发明人 |
CHOU CHUAN-CHU;MURGOLO NICHOLAS J.;ABRAMS JOHN S.;JENH CHUNG-HER;PETRO MARY E.;SILVER JON E.;TINDALL STEPHEN;WINDSOR WILLIAM T.;ZAVODNY PAUL J. |
分类号 |
C12N15/02;A61K38/00;A61K39/395;A61P37/00;C07K16/24;C07K16/46;C12N5/10;C12N15/09;C12N15/13;C12P21/08;C12R1/91;(IPC1-7):C07K16/00;C07H21/04 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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