| 摘要 |
A process is provided for the preparation of a variety of triggerable dioxetanes bearing alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy substituents from a common intermediate along with sulfur-substitute d dioxetanes and vinyl sulfide compounds used as intermediates. Alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy substituted dioxetane s are useful in detecting activating agents and in assays such as immunoassays and nucleic acid hybridization assays. The sulfur-substituted dioxetanes additionally are useful for producing chemiluminescence. The novel process involves conversion of a vinyl sulfide compound to a sulfur-substituted dioxetane, reacting the sulfur-substituted dioxetane with an electrophilic agent and a hydroxylic compound or salt thereof and forming the alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy-substituted dioxetane .
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