发明名称 |
Sea-trosy and related methods |
摘要 |
A method for preferentially observing an exposed position (1c) of a macromolecule. A sample is obtained having a macromolecule (1a) with a first proton (1) and a second molecule (2a) with a second proton (2); then applying a magnetic field (4) to the sample and irradiating the sample with a pulse sequence (5) that preferentially demagnetizes protons of the macromolecule (1, 3) relative to the second proton (2); allowing the second proton (2) to exchange (6) with an exposed proton (1) of the macromolecule; and detecting the magnetization from the relatively magnetized second proton (2), which is now bound to the exposed position (1c) of the macromolecule. The invention also provides a method for observing a position in the macromolecule that bind a ligand.
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申请公布号 |
US2002127731(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
US20010032140 |
申请日期 |
2001.12.19 |
申请人 |
SEM DANIEL S.;PELLECCHIA MAURIZIO |
发明人 |
SEM DANIEL S.;PELLECCHIA MAURIZIO |
分类号 |
G01R33/465;G01N33/15;G01R33/46;(IPC1-7):G01N33/00 |
主分类号 |
G01R33/465 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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