发明名称 |
Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation |
摘要 |
The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof which are specific, potent and safe inhibitors of the Ca2+-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.
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申请公布号 |
US2002128256(A1) |
申请公布日期 |
2002.09.12 |
申请号 |
US20010880728 |
申请日期 |
2001.06.13 |
申请人 |
BRUGNARA CARLO;HALPERIN JOSE;FLUCKIGER RUDOLF;BELLOTT EMILE M.;LOMBARDY RICHARD JOHN;CLIFFORD JOHN J.;GAO YING-DUO;HAIDAR REEM M.;KELLEHER EUGENE W.;MOUSSA ADEL M.;SACHDEVA YESH P.;SUN MINGHUA;TAFT HEATHER N. |
发明人 |
BRUGNARA CARLO;HALPERIN JOSE;FLUCKIGER RUDOLF;BELLOTT EMILE M.;LOMBARDY RICHARD JOHN;CLIFFORD JOHN J.;GAO YING-DUO;HAIDAR REEM M.;KELLEHER EUGENE W.;MOUSSA ADEL M.;SACHDEVA YESH P.;SUN MINGHUA;TAFT HEATHER N. |
分类号 |
A61K31/045;A61K31/075;A61K31/122;A61K31/15;A61K31/165;A61K31/216;A61K31/222;A61K31/235;A61K31/277;A61K31/336;A61K31/357;A61K31/404;A61K35/20;(IPC1-7):A61K31/55;A61K31/474;A61K31/407;A61K31/405 |
主分类号 |
A61K31/045 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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