STIMULATION OF CARTILAGE GROWTH WITH AGONISTS OF THE NON-PROTEOLYTICALLY ACTIVATED THROMBIN RECEPTOR
摘要
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
申请公布号
WO0207748(A3)
申请公布日期
2002.09.12
申请号
WO2001US22668
申请日期
2001.07.19
申请人
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYST;CARNEY, DARRELL, H.;CROWTHER, ROGER, S.;STIERNBERG, JANET;BERGMANN, JOHN
发明人
CARNEY, DARRELL, H.;CROWTHER, ROGER, S.;STIERNBERG, JANET;BERGMANN, JOHN