发明名称 |
NUCLEIC ACIDS ENCODING ZINC METALLOPROTEASES |
摘要 |
Isolated mammalian proteins having disintegrin-like and metalloprotease domains with thrombospondin type I motifs, i.e., ADAMTS proteins, are provided. The proteins are ADAMTS-5, ADAMTS-6, ADAMTS-7, ADAMTS-8, ADAMTS-9 and ADAMTS-10, collectively referred to as "ADAMTS-N". The present invention also provides isolated polynucleotides which encode an ADAMTS-N protein or a variant thereof, polynucleotide sequences complementary to such polynucleotides, vectors containing such polynucleotides, and host cells transformed or transfected with such vectors. The present invention also relates to antibodies which are immunospecific for one or more of the ADAMTS-N proteins. The present invention also relates to a protein referred to hereinafter as ADAMTS-R1 (ADAM-TS Related protein-1) and the polynucleotides which encode such protein.
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申请公布号 |
WO0111074(A9) |
申请公布日期 |
2002.09.12 |
申请号 |
WO2000US21223 |
申请日期 |
2000.08.03 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION;APTE, SUNEEL, S.;HURSKAINEN, TIINA, L.;HIROHATA, SATOSHI |
发明人 |
APTE, SUNEEL, S.;HURSKAINEN, TIINA, L.;HIROHATA, SATOSHI |
分类号 |
C12N9/64;(IPC1-7):C12Q/ |
主分类号 |
C12N9/64 |
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