<p>This invention relates to sulfamides of formula (I) wherein R<SP>10</SP> is C(O)OH or C(O)-NR<SP>11</SP>-OR<SP>12</SP> and the other R symbols may be a wide variety of substituents including where R<SP>1</SP> and R<SP>2</SP> together with the C atom to which they are attached form a carbocycle or hetrocycle, where R<SP>3</SP> and R<SP>1</SP> or R<SP>2</SP> and the atoms to which they are attached form a heterocycloamino group, where R<SP>20</SP> and R<SP>21</SP> together with the N atom to which they are attached form a heterocycloamino group and where either of R<SP>20</SP> or R<SP>21</SP> together with R<SP>3</SP> forms an alkylene group. They are inhibitors of metalloproteases, (MMP inhibitors) for use in treating disorders of connective tissue.</p>
申请公布号
EP0958287(B1)
申请公布日期
2002.09.11
申请号
EP19980907943
申请日期
1998.01.14
申请人
F. HOFFMANN-LA ROCHE AG;AGOURON PHARMACEUTICALS, INC.