| 摘要 |
PROBLEM TO BE SOLVED: To improve percutaneous absorptivity and transmucosal absorptivity of a water-soluble active ingredient by increasing the amount of the sealed water-soluble active ingredient in an inner aqueous phase because a W/O/W type composite emulsion having a high concentration of composite particles, a high inner aqueous phase ratio and excellent preservation stability is obtained. SOLUTION: The W/O/W type composite emulsion is obtained by dispersing W/O type emulsion particles in an outer aqueous phase, comprises (A) the water- soluble active ingredient, (B) a nonpolar oil and (C) a hydrophilic polyglycerol ester of a fatty acid, and is characterized in that the content of a polyoxyethylene type nonionic surfactant having >=15 number of added mol of plyoxyethylene groups is <=1 mass% and the ratio of the total content of the W/O type emulsion particles to the content of the outer aqueous phase is (45:55) to (99:1) of the W/O type emulsion particles:outer aqueous phase expressed in terms of mass ratio.
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