发明名称 |
Processes for producing optically active 2-amino-1-phenylethanol derivatives |
摘要 |
<p>An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) <CHEM> wherein R<1> and R<5> represent a hydrogen atom, etc.; R<2>, R<3> and R<4> independently represent a halogen atom, etc., or a salt thereof, can readily be produced (1) by permitting a microorganism belonging to the genus Rhodosporidium, the genus Comamonas or the like to act on a mixture of corresponding (R)-form and (S)-form to asymmetrically utilize, or (2) by permitting a microorganism belonging to the genus Lodderomyces, the genus Pilimelia or the like to act on a corresponding aminoketone derivative to asymmetrically reduce. An (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl) amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (IIa) or a salt thereof. Said derivative is useful as an intermediate for producing an anti-obesity agent and so on.</p> |
申请公布号 |
EP0939134(B1) |
申请公布日期 |
2002.09.11 |
申请号 |
EP19990107402 |
申请日期 |
1994.11.18 |
申请人 |
DAICEL CHEMICAL INDUSTRIES, LTD. |
发明人 |
FURUKAWA, KAZUAKI;ABE, TAKAYUKI;AKAMATSU, HIDEKAZU;MATSUYAMA, AKINOBU;ITO, MICHIO;YAMASAKI, NORITSUGU;MIKI, KATSUYA;IKURA, KIYOSHI;ISHIGURO, TAKESHI |
分类号 |
C07C213/00;C07C213/04;C07C213/08;C07C213/10;C07C215/08;C07C231/18;C12P7/22;C12P13/00;C12P41/00;(IPC1-7):C12P13/00 |
主分类号 |
C07C213/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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