| 摘要 |
The present invention provides, in its principal aspect, compounds of the general formula:whereA is -NHCO-, -N(CH3)-CO-, -NHCH2-, -N(CH3)-CH2-, -COCH2-, -CH2CH2-, or -CH(OH)CH2-,X is H, CH3, NH2, NH(CH3), N(CH3)2, OCH3, or SH;R2 is hydrogen or a methyl or ethyl group;R3 is hydrogen or a methyl or ehtyl group;n is 0, 1, 2, 3, 4, 5 or 6;R1 is selected from the group consisting of (a) alkyl; (b) C3 to C8 cycloalkyl; (c) phenyl or substituted phenyl; (d) heterocyclic; (e) decahydronaphthalene and (f) octahydroindane; or R1 and X may be taken together to denote a 5,6 or 6,6 saturated bicycle ring structure.The compounds of the present invention have H3 histamine receptor antagonist activity. This invention also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with an effective amount of a compound of formula 1.0. The present invention also provides a method of treating conditions in which antagonism of histamine H3 receptors may of therapeutic importance.
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