LABORATORY SCALE MILLING PROCESS

摘要

There is provided a process fo reducing particle size of a drug, the process comprising: (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 mu m; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.