<p>The invention relates to the use of an influenza antigen preparation obtainable by the following process, in the manufacture of an intradermal flu vaccine: (i) harvesting of virus-containing material from a culture; (ii) clarification of the harvested material to remove non-virus material; (iii) concentration of the harvested virus; (iv) a further step to separate whole virus from non-virus material; (v) splitting of the whole virus using a suitable splitting agent for instance a detergent such as sodim deoxycholate in a density gradient centrifugation step; (vi) filtration to remove undesired materials; wherein the steps are performed in that outer but not necessarily consecutively.</p>
申请公布号
WO02067983(A1)
申请公布日期
2002.09.06
申请号
WO2002EP01843
申请日期
2002.02.21
申请人
SMITHKLINE BEECHAM BIOLOGICALS S.A.;GARCON, NATHALIE;SLAOUI, MONCEF, MOHAMED;VAN HOECKE, CHRISTIAN
发明人
GARCON, NATHALIE;SLAOUI, MONCEF, MOHAMED;VAN HOECKE, CHRISTIAN