| 摘要 |
<p>Novel tricyclic compounds having the formula (II) or (I), wherein: R1 is optionally substituted and selected from a member of the group consisting of hydrogen, methyl, C(1-20)alkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(1-20)hydroxyalkyl, C(1-20)cyanoalkyl, C(1-20)alkoxyl, and C(1-20)alkoxyalkyl; R2 and R3 join to form an optionally substituted heterocycle, each R2 and R3 being independantly selected from a member of the group consisting of hydrogen, halo, thio, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylthio, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkyloxyalkenyl, C(1-20)aminoalkyloxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(1-20)tetraaminoalkyl, C(1-20)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(1-20)alkoxyl, C(1-20)alkoxyalkyl, and C(1-20)dialkoxyalkyl, are found to be used for the treatment or prevention of symptoms of manifestations associated with diseases or disorders affected by cytosine and intracellular signaling.</p> |
