发明名称 |
A process for the preparation of disodium pamidronate |
摘要 |
<p>A process for the preparation of disodium pamidronate, which process comprises the following steps: a) treatment of an aqueous suspension of pamidronic acid with a sodium hydroxide aqueous solution until obtaining a clear solution; b) filtration of the resulting solution, addition of a solvent and subsequent azeotropical distillation of water; c) cooling of the resulting solution and precipitation of the product. The resulting sodium pamidronate contains water in percentage from 5 to 11%.</p> |
申请公布号 |
EP1236733(A1) |
申请公布日期 |
2002.09.04 |
申请号 |
EP20020003891 |
申请日期 |
2002.02.21 |
申请人 |
BIOINDUSTRIA LABORATORIO ITALIANO MEDICINALI S.P.A. |
发明人 |
CARACCIA, NICOLA;CASTELLARI, FRANCO;GATTI, PIER ANDREA;GIORDANI, CRISTIANA;TARDITI, ROBERTO |
分类号 |
C07F9/38;(IPC1-7):C07F9/38 |
主分类号 |
C07F9/38 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|