发明名称 |
Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates |
摘要 |
Oligonucleotides conjugated to carbohydrates and methods for their production are described. These oligonucleotide-carbohydrate conjugates are resistant to degradation by nucleases, are able to form stable duplexes with RNA, and have utility as inhibitors of gene expression.
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申请公布号 |
US6444806(B1) |
申请公布日期 |
2002.09.03 |
申请号 |
US19970837651 |
申请日期 |
1997.04.22 |
申请人 |
HISAMITSU PHARMACEUTICAL CO., INC. |
发明人 |
VEERAPANANI DANGE;NOZAWA IWAO |
分类号 |
C12N15/09;A61K31/70;A61K48/00;C07H21/00;C07H21/04;C12N15/113;C12P19/34;(IPC1-7):C07H21/00;A01N43/04;G01N33/566 |
主分类号 |
C12N15/09 |
代理机构 |
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