| 摘要 |
It is intended to develop drugs capable of directly or indirectly inhibiting the activation of caspase. More specifically speaking, caspase 3 inhibitors containing proteins having an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:31 or salts thereof. These proteins, peptide fragments thereof or salts thereof are useful as drugs such as preventives and/or remedies for AIDS, fulminant hepatitis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, pigmentary retinopathy, cerebellar denaturation, myelodysplastic syndrome, aplastic anemia, sideroblastic anemia, myocardial ischemia, conduction failure, chronic heart failure, graft-versus-host disease, congenital or acquired enzymatic failure , etc.
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