TARGET COMPLEX AS AN AGENT FOR INHIBITING TUMOUR CELLS AND FOR STIMULATING ANGIOGENESIS
摘要
The invention relates to novel agents for influencing tumour growth or angiogenesis. Inhibitors of the protein kinase D and the protein kinase 2 which are associated with the COP9 signalosome (target complex) are used as effective agents for inhibiting tumour growth. Activators of the kinases associated with the target complex are used to activate angiogenesis. The inventive use of inhibitors of the kinases associated with the target complex is reflected in the triggering of apoptosis in tumour cells and in the inhibition of tumour angiogenesis and metastatic spread. The activators stimulate the formation of new blood vessels.
申请公布号
WO02066021(A2)
申请公布日期
2002.08.29
申请号
WO2002DE00652
申请日期
2002.02.21
申请人
UNIVERSITAETSKLINIKUM CHARITE MEDIZINISCHE FAKULTAETDER HUMBOLDT-UNIVERSITAET ZU BERLIN;PREISSNER, ROBERT;DUBIELL, WOLFGANG;GOEDE, ANDREAN;FROEMMEL, CORNELIUS
发明人
PREISSNER, ROBERT;DUBIELL, WOLFGANG;GOEDE, ANDREAN;FROEMMEL, CORNELIUS