COMPOSITIONS WITH CONTROLLED DRUG RELEASE

摘要

Compositions with controlled drug release comprising a water-soluble polymer, an enteric polymer, an additive showing an alkaline pH value when suspended or dissolved in water and a drug. From these compositions, a drug can be hardly eluted in the stomach but released under control in the lower parts of the digestive tracts (lower part of the small intestine, the large intestine, etc.) while not so largely affected by pH changes. Thus, these compositions are characterized by being capable of delivering a drug selectively to the lower part of the small intestine and the large intestine.