RGD-ANALOG NON-PEPTIDIC MOLECULES HAVING ANTI-ADHESIVE, ANTI-MIGRATION AND ANTI-PROLIFERATIVE EFFECTS

摘要

Molecules of the general formula (I) without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif "arginine-glycine-aspartic acid" (that is a potent inhibitor, in vivo and in vitro , of cellular adhesion). In vitro experimentation demonstrated that said molecules are efficient inhibitors of RASMC adhesion, proliferation and migration.