| 摘要 |
The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally -5° C., thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents. |
