摘要 |
A benzothiazole compound of formula I or a salt thereof where p is 0,1, 2 or 3; X1 and X2 are each hydrogen, or together form =O or =S; each R1 is independently hydrogen, R6, -OH, -OR6, -SH, -SR6, -C(O)qH, -C(O)qR6, -O-C(O)qR6, -S(O)qR6; halo; cyano; nitro; -Z4-NR7R8; -Z4-N(R9)-Z5-NR10OR11; -Z4-N(R12)-Z5-R6; -SO3H, -P(O)(OR6)2; or any two groups R1 may together with the carbon atoms to which they are attached form a 3-to 8-membered optionally saturated optionally substituted ring, R2 and R3 are each independently hydrogen or R6; -Z4-R6 or -Z13-NR7R8; R4 and R5 are each independently hydrogen or R6 or together with the nitrogen atom to which they are attached form a 3-to 8-membered optionally saturated optionally substituted heterocyclic ring which heterocyclic ring which may be fused to an optionally substituted benzene ring; q and R6 to R14 are as defined in the specification; Z4 and Z5 are each independently a single bond; -Z11-S(O)q-Z12-; -Z11-C(O)-Z12-; -Z11-C(S)-Z12-; -Z11-O-Z12-; -Z11-S-Z12-; -Z11-O-C(O)-Z12-; or -Z11-C(O)-O-Z12-; Z11 and Z12 are each independently a single bond; alkylene; alkenylene; or alkynylene; Z13 is a single bond; -Z11-S(O)q-Z12-; -Z11-C(O)-Z12-; -Z11-C(S)-Z12-; -Z11-O-Z12-; -Z11-S-Z12-; -Z11-O-C(O)-Z12-; -Z11-C(O)-O-Z12-; -C (NR13)-; -C (CHR14)- ; or -C(C(R14)2)-. This compound can be used for the treatment of protein tyrosine kinase associated disorder.
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