INFLUENZA VIRUSES WITH ENHANCED TRANSCRIPTIONAL AND REPLICATIONAL CAPACITIES

摘要

The present invention provides human influenza viruses comprising an RNA-sequence encoding a modified RNA-polymerase, a process for the preparation thereof, pharmaceutical compositions comprising said human influenza viruses and their use for gene transfer into mammalian cells, for ex vivo gene transfer into antigen-presenting cells, such as dendritic cells, for in vivo somatic gene therapy, or in vivo vaccination purposes. The invention also relates to other non-avian influenza viruses, including equine, porcine (swine) influenza viruses.