CRYSTALLIZED PPAR DOLLAR G(A) LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME
摘要
A solved three-dimensional crystal structure of a PPAR alpha ligand binding domain polypeptide is disclosed, along with a crystal form of the PPAR alpha ligand binding domain polypeptide. Methods of designing modulators of the biological activity of PPAR alpha and other PPAR ligand binding domain polypeptides are also disclosed.
申请公布号
WO02064632(A2)
申请公布日期
2002.08.22
申请号
WO2002US03278
申请日期
2002.01.31
申请人
SMITHKLINE BEECHAM CORPORATION;LAMBERT, MILLARD, HURST, III;MONTANA, VALERIE, GAIL;XU, HUAQIANG, ERIC
发明人
LAMBERT, MILLARD, HURST, III;MONTANA, VALERIE, GAIL;XU, HUAQIANG, ERIC