发明名称 Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
摘要 The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40° C. and 50° C.
申请公布号 US2002115664(A1) 申请公布日期 2002.08.22
申请号 US20010000537 申请日期 2001.10.19
申请人 发明人 CROCKER LOUIS S.;CLARKE WILLIAM F.;KUKURA JOSEPH L.;THOMPSON ANDREW S.
分类号 C07D265/18;(IPC1-7):C07D265/18 主分类号 C07D265/18
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