摘要 |
Pulmonary disorders in which the GSNO pool or glutathione pool in the lung i s depleted and where reactive oxygen species in lung are increased, are treate d by deliverying into the lung as a gas, agent causing repletion or increase o f the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.
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