发明名称 2 beta-substituted-6-alkylidene penicillanic acid derivatives as beta-lactamase inhibitors
摘要 Compound of formula I:wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting beta-lactamase enzymes, for enhancing the activity of beta-lactam antibiotics, and for treating beta-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
申请公布号 US6436398(B2) 申请公布日期 2002.08.20
申请号 US20000725611 申请日期 2000.11.29
申请人 RESEARCH CORPORATION TECHNOLOGIES, INC. 发明人 BUYNAK JOHN D.;RAO AKIREDDY SRINIVASA;DOPPALAPUDI VENKATA RAMANA
分类号 A61K31/43;C07D499/00;C07D499/04;C07D499/44;C07D499/86;C07D499/87;C07D499/897;(IPC1-7):A61K35/00 主分类号 A61K31/43
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