| 摘要 |
organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of 10,11-dihydro-10- oxo-5H-dibenzo-[b,f]azepine-5-carboxamide of the general formula (I) where R means hydroxy- group or group O-CO-R1 where R1 means hydrogen atom, alkyl group, heteroaryl group, or R means group O-CO-OR1 where R1 is determined above; or R means group O-R2 where R2 means alkyl or alkylaryl; or R means NR3R4 where R3 means hydrogen atom, group NH-CO-NH2, NH-CS-NH2, and R4 means hydrogen atom, alkyl, alkylcarbonyl. Values of terms "alkyl", "aryl", "heteroaryl" and "halogen" are disclosed in the invention claim. Invention describes also methods of synthesis of indicated compounds, a pharmaceutical composition based on thereof and a method of treatment of convulsant states. Invention can be used in medicine in treatment of some diseases of the central and peripheral nervous system. EFFECT: new compounds indicated above, improved methods of synthesis, valuable medicinal properties. 14 cl
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