发明名称 |
Prodrugs of aspartyl protease inhibitors |
摘要 |
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.
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申请公布号 |
US6436989(B1) |
申请公布日期 |
2002.08.20 |
申请号 |
US19970998050 |
申请日期 |
1997.12.24 |
申请人 |
VERTEX PHARMACEUTICALS, INCORPORATED |
发明人 |
HALE MICHAEL R.;TUNG ROGER D.;BAKER CHRISTOPHER T.;SPALTENSTEIN ANDREW |
分类号 |
A61K31/18;A61K31/215;A61K31/265;A61K31/27;A61K31/34;A61K31/341;A61K31/4025;A61K31/496;A61K31/66;A61K31/661;A61K31/664;A61K31/7048;A61K45/00;A61P31/12;A61P31/18;A61P43/00;C07C311/15;C07C311/18;C07C311/37;C07D277/30;C07D307/20;C07D405/12;C07D407/12;C07D417/12;C07F9/655;C07F9/6584;C07H15/04;C07H15/26;(IPC1-7):A61K31/665;C07F9/06;C07F9/28 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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