发明名称 |
VARIANTS OF TRAF2 WHICH ACT AS AN INHIBITOR OF TNF-ALPHA (TNF alpha) SIGNALING PATHWAY. |
摘要 |
<p>The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF alpha signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated-deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF alpha signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF alpha binding.</p> |
申请公布号 |
MXPA01011107(A) |
申请公布日期 |
2002.08.09 |
申请号 |
MX2001PA11107 |
申请日期 |
2000.04.06 |
申请人 |
AVENTIS PHARMACEUTICALS INC. |
发明人 |
GUO, KUN |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P1/00;A61P3/10;A61P9/00;A61P9/08;A61P9/10;A61P17/02;A61P19/02;A61P25/28;A61P29/00;A61P37/02;A61P43/00;C07K14/47;C07K14/715;C12N15/12;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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