IMPLANTABLE BIOARTIFICIAL ACTIVE SECRETION SYSTEM

摘要

An implantable bioartificial active secretion system for providing a physiological secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing (10) implantable within the host in fluidic communication with tissue fluid indicative of secretion need. A chamber (26)within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells (32) for producing the physiological secretion. A periodically operating apparatus (38) moves tissue fluid into contact with the secretory cells for pick up of the physiological secretion for subsequent physiologically-effective dispensing into the host while preventing access of immunorejection antigens to the host body.