发明名称 |
Method of inhibiting stenosis and restenosis |
摘要 |
The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD 18 or CCR2.
|
申请公布号 |
US2002106369(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
US20010809739 |
申请日期 |
2001.03.15 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
HORVATH CHRISTOPHER J.;RAO PATRICIA E. |
分类号 |
A61K45/06;A61K39/395;A61M29/02;A61M31/00;A61P9/10;A61P9/14;C07K16/28;C07K16/36;(IPC1-7):A61K39/395 |
主分类号 |
A61K45/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|